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Abstract #1950

In Vivo Current Density Distribution of Brain during Electrical Stimulation

Nitish Katoch1, Bup Kyung Choi1, Saurav ZK Sajib1, Jin Woong Kim2, Hyung Joong Kim1, Oh In Kwon3, and Eung Je Woo1

1Kyung Hee University, Seoul, Korea, Republic of, 2Radiology, Chonnam National University Medical School, Gwangju, Korea, Republic of, 3Konkuk University, Seoul, Korea, Republic of

In deep brain stimulation, in vivo mapping of brain response is indispensable to secure its clinical applications. Estimation of current density distribution by stimulating currents can provide alternative way for understanding the therapeutic effects in electrical stimulation. MREIT method enables high-resolved mapping of electromagnetic tissue properties such as current density and conductivity of living tissues. In this study, we experimentally imaged current density distribution of in vivo canine brains by applying MREIT to electrical stimulation. The resulting current pathway and volume activation may provide useful information for adjusting the surgical planning and proving the therapeutic effects of DBS.

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