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Abstract #1955

Evaluating The Accuracy of Susceptibility Maps Calculated from Single-Echo versus Multi-Echo Gradient-Echo Acquisitions

Emma Biondetti1, Anita Karsa1, David L Thomas2, and Karin Shmueli1

1Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 2Leonard Wolfson Experimental Neurology Centre, Institute of Neurology, University College London, London, United Kingdom

For Susceptibility Mapping (SM), Laplacian-based methods (LBMs) can be used on single- or multi-echo gradient echo phase data. Previous studies have shown the advantage of using multi-echo versus single-echo data for noise reduction in susceptibility-weighted images and simulated data. Here, using simulated and acquired images, we compared the performance of two SM pipelines that used multi- or single-echo phase data and LBMs. We showed that the pipeline that fits the multi-echo data over time first and then applies LBMs gives more accurate local fields and $$$\chi$$$ maps than the pipelines that apply LBMs to single-echo phase data.

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