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Abstract #1965

Assessment of melanin content and its influence on susceptibility contrast in melanoma metastases

Sina Straub1, Frederik B. Laun1,2, Martin T. Freitag3, Christian Kölsche4,5, Heinz-Peter Schlemmer3, Mark E. Ladd1, and Till Schneider3,6

1Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 3Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 4Department of Neuropathology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany, 5German Cancer Consortium (DKTK), CCU Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 6Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany

Melanoma metastases can be classified as melanotic or amelanotic based on their T1-weighted magnetic resonance signal. However, the underlying contrast mechanisms have remained unclear and have been attributed to melanin and/or blood products. In this study, non-hemorrhagic cerebral melanoma metastases were investigated using quantitative susceptibility mapping. Susceptibility values for metastases with no, small or high melanin content were very similar (‑0.023±0.046 ppm / -0.006±0.02 ppm / -0.018±0.017 ppm). Non-hemorrhagic melanoma metastases show weakly diamagnetic susceptibility values and melanin is not a source of strong susceptibility.

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