Abstract #1965

Assessment of melanin content and its influence on susceptibility contrast in melanoma metastases

Sina Straub¹, Frederik B. Laun^1,2, Martin T. Freitag³, Christian Kölsche^4,5, Heinz-Peter Schlemmer³, Mark E. Ladd¹, and Till Schneider^3,6

¹Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ²Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, ³Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁴Department of Neuropathology, Institute of Pathology, University of Heidelberg, Heidelberg, Germany, ⁵German Cancer Consortium (DKTK), CCU Neuropathology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁶Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany

Melanoma metastases can be classified as melanotic or amelanotic based on their T1-weighted magnetic resonance signal. However, the underlying contrast mechanisms have remained unclear and have been attributed to melanin and/or blood products. In this study, non-hemorrhagic cerebral melanoma metastases were investigated using quantitative susceptibility mapping. Susceptibility values for metastases with no, small or high melanin content were very similar (‑0.023±0.046 ppm / -0.006±0.02 ppm / -0.018±0.017 ppm). Non-hemorrhagic melanoma metastases show weakly diamagnetic susceptibility values and melanin is not a source of strong susceptibility.

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