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Abstract #1992

Quantification of Hepatic Fat Fraction and Liver/Spleen R2* in a Healthy Cohort at 3 Tesla

Rosalind Gerson1, Chris Bowen2,3, Manjari Murthy2, and Sharon Clarke2,3

1School of Medicine, Dalhousie University, Halifax, NS, Canada, 2Biomedical Translational Imaging Centre, QEII Health Sciences Centre, Halifax, NS, Canada, 3Department of Diagnostic Radiology, Dalhousie University, Halifax, NS, Canada

Non-invasive quantification of hepatic fat and iron with MRI has generated increasing clinical interest, particularly given the prevalence of chronic liver disease. Elevated R2* is a biomarker of iron deposition in the liver and spleen. The normative distribution of R2* in these organs at 3T is not well described, but is necessary for confident diagnosis of mild to moderate levels of iron deposition. Based on measurements in 97 adults selected from the general population, we confirm that ~20% have fatty liver and suggest that a hepatic R2* > 89 s-1 and splenic R2* > 69 s-1 can be considered abnormal.

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