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Abstract #2003

Quantitative Assessment of Hepatic function with Hepatocyte Fraction

Mengqi He1, Yingjie Mei2,3, Jing Zhang1, Zeyu Zheng1, Hongxiang Li1, Tomoyuki Okuaki4, Eunju Kim5, and Yikai Xu1

1Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China, 2Guangdong Provincial Key Laboratory of Medical Image Processing,School of Biomedical Engineering,Southern Medical University, Guangzhou, People's Republic of China, 3Philips Healthcare, Guangzhou, China., 4MR Clinical Science, Philips Healthtech, Tokyo, Japan, 5MR Clinical Science, Philips Healthcare, Seoul, Korea

Gadoxetic acid has been shown to evaluate liver function as it is known to be actively taken up by hepatocytes via organic anion transporters (OATPs). The measurement of hepatic parenchymal enhancement during the hepatobiliary phase (HBP) may accurately reflect liver function. This study evaluated the liver function of the subject in the Child-Pugh classification method which is still the most commonly applied method for evaluating liver function in clinical. The hepatocyte fractions were significantly different among groups classified according to Child–Pugh scores between A and C, B and C. The hepatocyte fraction could be considered as a promising method for the quantitative assessment of liver function.

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