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Abstract #2018

Liver Iron Concentration determined with Gradient Echo MRI by Signal Intensity Ratio: Effects of Patient Characteristics

Arthur Peter Wunderlich1,2, Holger Cario3, Isabelle Tomczak1, Meinrad Beer1, and Stefan Andreas Schmidt1

1Diagnostic and Interventional Radiology, Ulm University, Medical Center, Ulm, Germany, 2Section for Experimental Radiology, Ulm University, Medical Center, Ulm, Germany, 3Department of Pediatrics and Adolescent Medicine, Ulm University, Medical Center, Ulm, Germany

To investigate the relation between signal intensity ratios gained from gradient echo (GRE) MRI and liver iron concentration (LIC), we studied the influence of patient characteristics. 168 patients (71 f, 97 m; 49 with Thalassemia major, 101 without Thalassemia) suspected for liver iron overload were scanned according to Ferriscan® with spin echo MRI to obtain reference LIC values, and GRE protocols suitable for LIC determination. GRE analysis by manually drawn liver and muscle ROIs yielded liver-to-muscle signal intensity ratios (SIR). Correlation analysis of ln (SIR) to reference LIC revealed differences between patient subgroups concerning disease, gender and age.

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Abstract