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Abstract #2033

Gadolinium-enhanced high-flip-angle R2* mapping enables estimation of a greater range of R2* values

Jonathan Hooker1, Yesenia Covarrubias1, Cheng William Hong1, Soudabeh Fazeli Dehkordy1, Adrija Mamidipalli1, Ethan Z Sy1, Gavin Hamilton1, and Claude B Sirlin1

1Liver Imaging Group, Department of Radiology, University of California, San Diego School of Medicine, San Diego, CA, United States

The range of R2* values estimated from MR sequences using low flip angles (FA) is limited by the background signal decay. The administration of contrast allows the use of higher FAs and increases the signal to noise ratio (SNR), allowing the estimation of a greater range of R2* values. We compared pre- and post-contrast R2* values in 158 patients and observed large discrepancies at R2* values greater than 300s-1. Our findings suggest that in patients with severe iron overload, post-contrast high-FA R2* mapping may be the preferred sequence for iron quantification.

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