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Abstract #2040

Optimisation for Pulmonary R2* Quantification and Repeatability Evaluation

Alex Weller1, Matthew Orton1, David Collins1, James D'Arcy1, and Nandita de-Souza1

1Radiotherapy and Imaging, The Institute of Cancer Research, Surrey, United Kingdom

In 5 patients with lung cancer, UTE-MRI was used to derive pulmonary R2* in lung and establish its repeatability. Plausible R2* values were obtained only when using TEs of 0.08 and 0.2 ms: higher TEs produced implausible mean negative R2* within individual patients and a cohort R2* not significantly different from zero, due to lack of signal decay beyond TE=0.2ms. Pulmonary R2* values derived using TEs of 0.08 and 0.2ms were higher than prior reports where longer echo-times were employed. Test-retest limits-of-agreement were +90.5%to -47.5% indicating that a 90% increase in R2*is required post-radiotherapy to reliably demonstrate radiation-induced change.

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