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Abstract #2050

Receiver operating characteristic analysis of fat-fraction is effective in differentiating identifying an optimal threshold to differentiate between brown and white adipose tissue ex vivo and in situ in rats using 3-point IDEAL MRI

Terence Jones1,2, Narendra Reddy3, Sarah Wayte4, Thomas Barber2,3, and Charles Edward Hutchinson1,2

1Department of Radiology, University Hospitals Coventry & Warwickshire NHS Trust, Birmingham, United Kingdom, 2Warwick Medical School, University of Warwick, Coventry, United Kingdom, 3Department of Endocrinology, University Hospitals Coventry & Warwickshire NHS Trust, Birmingham, United Kingdom, 4Medical Physics, University Hospitals Coventry & Warwickshire NHS Trust, Coventry, United Kingdom

Brown adipose tissue (BAT) has lower fat content than white adipose tissue (WAT), which has been exploited using Dixon-based MRI to identify BAT. We sought to identify the optimal threshold to differentiate between BAT and WAT in rats on the basis of fat fraction.

Fat fraction within BAT was significantly lower than WAT in rodents. Receiver operating characteristic analysis showed that differentiating BAT and WAT on the basis of fat fraction had excellent accuracy in both ex vivo and in situ. The optimal cut-off to separate BAT and WAT was significantly lower in rats exposed to cold, likely secondary to lipolysis.

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