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Abstract #2052

Resistance and susceptibility to diabetes - characterising the ‘Thin on the Outside Fat on the Inside’ (TOFI) profile using magnetic resonance imaging: a pilot study in Asian and Caucasian women

Ivana R Sequeira1, Wilson Yip1, Louise WW Lu1, Reza Nemati2, Dech Dokpuang2, Jun Lu2, and Sally D Poppitt1

1Human Nutrition Unit, School of Biological Sciences, University of Auckland, Auckland, New Zealand, 2Faculty of Health and Environmental Sciences, Auckland University of Technology, Auckland, New Zealand

Prediction of risk for dysglycaemia and adverse metabolic health is difficult, with some outwardly lean individuals having greater susceptibility to type 2 diabetes (T2D) than obese resilient individuals. Using 3T MR Imaging and spectroscopy we showed, in 10 Asian Chinese and 6 European Caucasian healthy or prediabetic women (18 – 70 years and BMI 25 – 50 kg/m2), that greater storage of fat within riskier ectopic sites, i.e. pancreas and liver, may in part explain the reported increased risk of T2D in Asian Chinese populations compared to their Caucasian counterparts at the same BMI and younger age.

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