Abstract #2059

Phosphorus MRSI reveals subtle changes in metabolic profile of hepatic tissue in insulin resistant population.

Lorenz Pfleger^1,2, Peter Wolf¹, Martin Gajdošík^1,2, Sabina Smajiš¹, Marek Chmelík³, Anton Luger¹, Siegfried Trattnig², Michael Krebs¹, and Martin Krššák^1,2

¹Endocrinology & Metabolism, Internal Medicine III, Medical University of Vienna, Wien, Austria, ²High-field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Wien, Austria, ³Clinical Molecular Imaging, Karl Landsteiner Institute, Wien, Austria

This study employed ultra-high field (7T) ¹H and ³¹P MRS for the characterization of subtle hepatic tissue changes in insulin sensitive and insulin resistant group of healthy volunteers. Hepatic lipids, the forward rate of ATP synthesis and profile of metabolites containing ³¹P were assessed. Decreased inorganic phosphate was found in the subgroup of volunteers with increased hepatic fat accumulation and increased phosphocholine was found in the insulin sensitive subgroup. Concentration of ³¹P containing metabolites found here are well within the range of previous publications and subtle differences point towards their role in pathophysiology of metabolic syndrome and/or hepatic steatosis.

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