Abstract #2062

Why is the Peripheral Zone of the Normal Human Prostate High in ADC Value and T2-Weighted Signal Intensity?

Edward William Johnston¹, Colleen Bailey², Elisenda Bonet-Carne², Hayley Pye³, Susan Heavey³, Dominic Patel⁴, Ashwin Sridhar⁵, Bernard Siow⁶, Thomy Mertzanidou², William Devine¹, Jagadish Kalasthry¹, Joey Clemente¹, David Hawkes², Hayley Whitaker³, Manuel Rodriguez-Justo⁴, Greg Shaw⁵, Daniel Alexander², Alexander Freeman⁴, Roger Bourne⁷, Eleftheria Panagiotaki², and Shonit Punwani¹

¹Centre for Medical Imaging, University College London, London, United Kingdom, ²Centre for Medical Image Computing, University College London, London, United Kingdom, ³Research Department for Tissue & Energy, University College London, London, United Kingdom, ⁴Department of Pathology, University College London Hospital, University Street, United Kingdom, ⁵Department of Urology, University College London Hospital, London, United Kingdom, ⁶Francis Crick Institute, University College London, London, United Kingdom, ⁷Discipline of Medical Radiation Sciences, University of Sydney, Sydney, Australia

The biophysical basis of MRI signal in the normal human prostate is uncertain, whereby the normal peripheral zone has high ADC values and returns high signal on T2-weighted imaging. In this study, we use MRI in combination with quantitative digital histopathology to offer an explanation. Paired scans were performed at 3T on a human prostate, prior to and following prostatectomy and changes in zonal morphology and MRI characteristics were measured. The peripheral zone collapsed and reduced in T2 signal intensity and ADC value ex-vivo. Digital histopathological analysis suggested the peripheral zone stores more ejaculatory fluid than the transition zone.

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