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Abstract #2062

Why is the Peripheral Zone of the Normal Human Prostate High in ADC Value and T2-Weighted Signal Intensity?

Edward William Johnston1, Colleen Bailey2, Elisenda Bonet-Carne2, Hayley Pye3, Susan Heavey3, Dominic Patel4, Ashwin Sridhar5, Bernard Siow6, Thomy Mertzanidou2, William Devine1, Jagadish Kalasthry1, Joey Clemente1, David Hawkes2, Hayley Whitaker3, Manuel Rodriguez-Justo4, Greg Shaw5, Daniel Alexander2, Alexander Freeman4, Roger Bourne7, Eleftheria Panagiotaki2, and Shonit Punwani1

1Centre for Medical Imaging, University College London, London, United Kingdom, 2Centre for Medical Image Computing, University College London, London, United Kingdom, 3Research Department for Tissue & Energy, University College London, London, United Kingdom, 4Department of Pathology, University College London Hospital, University Street, United Kingdom, 5Department of Urology, University College London Hospital, London, United Kingdom, 6Francis Crick Institute, University College London, London, United Kingdom, 7Discipline of Medical Radiation Sciences, University of Sydney, Sydney, Australia

The biophysical basis of MRI signal in the normal human prostate is uncertain, whereby the normal peripheral zone has high ADC values and returns high signal on T2-weighted imaging. In this study, we use MRI in combination with quantitative digital histopathology to offer an explanation. Paired scans were performed at 3T on a human prostate, prior to and following prostatectomy and changes in zonal morphology and MRI characteristics were measured. The peripheral zone collapsed and reduced in T2 signal intensity and ADC value ex-vivo. Digital histopathological analysis suggested the peripheral zone stores more ejaculatory fluid than the transition zone.

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