Variable refocusing flip angle single-shot fast spin echo (vrfSSFSE) decreases T2-decay related blurring, allows increased K-space coverage while maintaining clinically relevant echo times, and reduces specific absorption rate. We evaluated clinical image quality and acquisition time of vrfSSFSE for imaging liver lesions in comparison with conventional SSFSE in patients undergoing 68Ga-DOTA-TOC PET on a 3T time-of-flight PET/MRI. Quantitative analysis of 53 lesions in 27 patients demonstrated higher mean CNR with vrfSSFSE (9.9 vs. 6.7, p<0.001) and 1.7-fold increase in speed compared to SSFSE. vrfSSFSE improves liver lesion contrast with shorter scan times acquired using a single 20 second breath hold.
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