The predictive value of preoperative examination in differenciating high and low Gleason score of radical prostatectomy specimens

To evaluate the value of different preoperative examniations in differenciating high/low Gleason score, prostate volumev(PV), PSA, PSA density (PSAD), DRE, multiparametric MRI (mpMRI) and transrectal ultrasound guided biopsy were analyzed. The area under curve (AUC) of PSAD was 0.911 with the cut-off level of 0.25, which was even better than biopsy(AUC=0.887). MpMRI performed good diagnostic accuracy according to PI-RADS v2 by Reader 1(AUC=0.831) and 2(AUC=0.933).