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Abstract #2104

Estimating breast tumor blood flow during neoadjuvant chemotherapy using interleaved high temporal and high spatial resolution MRI

Leonidas Georgiou1, Nisha Sharma2, David Broadbent1,3, Daniel Wilson3, Barbara J Dall2, Anmol Gangi1,4, and David L Buckley1

1Division of Biomedical Imaging, University of Leeds, Leeds, United Kingdom, 2Department of Radiology, Leeds Teaching Hospital NHS Trust, 3Department of Medical Physics and Engineering, Leeds Teaching Hospital NHS Trust, 4Department of Western General Hospital, NHS Lothian

An ideal breast MRI protocol might include high spatial and high temporal resolution images acquired following a single contrast agent injection. Here we present an acquisition strategy to acquire both for clinical reporting and tracer kinetic analysis. The approach was evaluated using simulations and tested through application in patients undergoing neoadjuvant chemotherapy. Radiologists could adapt similar protocol strategies to examine the physiological characteristics of tumors and their associated changes during treatment without significantly compromising the data used for clinical reporting.

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