Increased breast density is a known risk factor for the development of breast cancer. Quantitative MRI methods have the potential to provide accurate, volumetric measures of breast tissue volume and density. A novel, confounder-corrected chemical shift encoded (CSE) MRI technique designed to provide accurate fibroglandular tissue volume and density quantification is validated using a fat and water phantom. The CSE MRI technique provided accurate quantification of water and volumes and was robust to changes in spatial resolution and complexity of fat/water interfaces, indicating this method is expected to produce accurate and robust quantification of fibroglandular and adipose tissue in-vivo.
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