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Abstract #2118

Comparison of whole tumor and single slice ROIs for measuring ADC in breast cancer

Jessica Gibbs1, Ella Jones1, Lisa Wilmes1, David C Newitt1, John Kornak1, Melanie Regan1, and Nola Hylton1

1University of California, San Francisco, CA, United States

Diffusion weighted imaging is a promising technique to monitor treatment response in patients undergoing pre-surgical chemotherapy, but manually drawn whole tumor measurements are time-consuming and subject to inter-user variability. In this study of 60 patients with sequential DWI exams during treatment, we measured apparent diffusion coefficient (ADC) from whole tumor ROIs and from a single central slice of the tumor. We found strong agreement in ADC between the two methods, suggesting that a slice from the center of the tumor may accurately represent the ADC of the entire tumor.

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