Abstract #2180

Measuring of Whole Brain Perfusion in the Awake Marmoset Using Continuous Arterial Spin Labeling

Cecil Chern-Chyi Yen¹, Wen-Yang Chiang^1,2, and Afonso C. Silva¹

¹Cerebral Microcirculation Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States, ²Biomedical Engineering, Texas A&M University, College Station, TX, United States

The common marmoset, a small New World primate, is a popular non-human primate for transgenic lines of brain disease models and 3D printed helmets to immobilize the head for awake MRI. However, cerebral blood flow (CBF), a crucial component to normal brain functions, has not been measured to date in awake marmosets. In this study, we demonstrate the feasibility of measuring whole brain CBF in the awake marmoset using a continuous arterial spin labeling MRI sequence and dedicated hardware, comprising of a spin-labeling coil and a novel 10-channel phased array in a 7T animal MRI system.

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