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Abstract #2234

A preliminary study on amide proton transfer-weighted MR imaging in patients with obsessive-compulsive disorder

Yan Li1, Naying He1, Hongmin Xu1, Chencheng Zhang2, Weibo Chen3, Yansong Zhao4, Yi Zhang5, Jinyuan Zhou5, Haiyan Jin6, and Fuhua Yan1

1Department of Radiology, Ruijin Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China, 2Department of Functional Neurosurgery, Ruijin Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China, 3Philips Healthcare, Shanghai, People's Republic of China, 4Philips Healthcare, Cleveland, OH, United States, 5Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 6Department of Psychiatry, Ruijin Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China

The aim of this study is to evaluate the feasibility of amide proton transfer-weighted (APTW) MR imaging to detect cerebral abnormalities in patients with obsessive-compulsive disorder (OCD) and to explore its clinical utility. Five OCD patients and 9 normal healthy controls (NC) underwent APTW MR imaging. The magnetic resonance ratio asymmetry (MTRasym) values at 3.5ppm of anterior cingulate cortex (ACC) and thalamus were measured on axial APTW images. We found a trend of increased MTRasym(3.5ppm) or APTW within ACC in OCD patients compared with controls. No significant difference was found between groups in the MTRasym(3.5ppm) within bilateral thalamus. Our results suggest that APTW imaging maybe a promising approach to investigate pathological changes underlying OCD and may provide insights into clinical diagnosis of OCD.

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