Abstract #2234

A preliminary study on amide proton transfer-weighted MR imaging in patients with obsessive-compulsive disorder

Yan Li¹, Naying He¹, Hongmin Xu¹, Chencheng Zhang², Weibo Chen³, Yansong Zhao⁴, Yi Zhang⁵, Jinyuan Zhou⁵, Haiyan Jin⁶, and Fuhua Yan¹

¹Department of Radiology, Ruijin Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China, ²Department of Functional Neurosurgery, Ruijin Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China, ³Philips Healthcare, Shanghai, People's Republic of China, ⁴Philips Healthcare, Cleveland, OH, United States, ⁵Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁶Department of Psychiatry, Ruijin Hospital,Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China

The aim of this study is to evaluate the feasibility of amide proton transfer-weighted (APTW) MR imaging to detect cerebral abnormalities in patients with obsessive-compulsive disorder (OCD) and to explore its clinical utility. Five OCD patients and 9 normal healthy controls (NC) underwent APTW MR imaging. The magnetic resonance ratio asymmetry (MTR_asym) values at 3.5ppm of anterior cingulate cortex (ACC) and thalamus were measured on axial APTW images. We found a trend of increased MTR_asym(3.5ppm) or APTW within ACC in OCD patients compared with controls. No significant difference was found between groups in the MTR_asym(3.5ppm) within bilateral thalamus. Our results suggest that APTW imaging maybe a promising approach to investigate pathological changes underlying OCD and may provide insights into clinical diagnosis of OCD.

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