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Abstract #2238

Different patterns of cortical matter changes in first episode bipolar manic adolescents: a surface-based structural MRI study with cluster analysis

Wenjing Zhang1, Wade Weber2, Huaiqiang Sun1, Min Wu1, Qiyong Gong1, Melissa DelBello2, and Su Lui1

1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, People's Republic of China, 2Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, United States

With an objective neuroimaging data-driven method using agglomerative hierarchical clustering analysis, two patterns of cortical matter changes among 58 first episode bipolar manic adolescents has been identified. And the clinical feature especially the intelligence quotient was corresponding to the subtyping among these patients. While the effect of medication and illness duration have been minimized, our findings provided new evidence indicating the existence of two neurobiologically distinct subgroups of patients with first episode bipolar mania, which may reflect qualitatively distinct genetic influences or neurodevelopmental alterations.

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