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Abstract #2244

Microstructure Alterations of Earthquake Survivors: A Longitudinal MR Diffusion Study

Linghui Meng1, Kaiming Li, and Jing Jiang

1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, People's Republic of China

To reveal how traumatic events affect the integrity of brain microstructure in trauma-exposed non-PTSD people, we performed a longitudinal tract-based spatial statistics (TBSS) analysis in earthquake survivors using diffusion tensor imaging (DTI) data collected 25 days (TimePoint 1) and 2 years (TimePoint 2) after the Wenchuan earthquake. Our results showed that fractional anisotropy (FA) in several brain regions at TimePoint 2 were significantly increased compared with those at TimePoint 1. The increased FA in these regions may serve as the underlying neural substrates as brain recovered from the trauma.

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