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Abstract #2261

Characterizing the Effect of Age on Measures of White Matter Integrity in the Optic Radiations of Children with and without Neurofibromatosis Type 1

Peter M K de Blank1, Michael J Fisher2, Marisa Prelack3, Amy Waldman3, and Jeffrey I Berman4

1Pediatrics, University Hospitals Rainbow Babies & Children, Cleveland, OH, United States, 2Pediatrics, The Children's Hospital of Philadelphia, 3Pediatric Neurology, The Children's Hospital of Philadelphia, 4Radiology, The Children's Hospital of Philadelphia

DTI measures in the optic radiations are a promising biomarker of vision in children with optic pathway gliomas, but normal values for fractional anisotropy (FA), radial diffusivity (RD), and mean diffusivity (MD) in young children have not been defined. In 40 children with neurofibromatosis type I (NF1) and 55 healthy control children between 0-14 years of age, we measured FA, RD and MD in the optic radiations. This study represents the first investigation of normal DTI measures in the optic radiations in young children and demonstrates an altered developmental trajectory in the optic radiations of children with NF1.

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