Abstract #2261

Characterizing the Effect of Age on Measures of White Matter Integrity in the Optic Radiations of Children with and without Neurofibromatosis Type 1

Peter M K de Blank¹, Michael J Fisher², Marisa Prelack³, Amy Waldman³, and Jeffrey I Berman⁴

¹Pediatrics, University Hospitals Rainbow Babies & Children, Cleveland, OH, United States, ²Pediatrics, The Children's Hospital of Philadelphia, ³Pediatric Neurology, The Children's Hospital of Philadelphia, ⁴Radiology, The Children's Hospital of Philadelphia

DTI measures in the optic radiations are a promising biomarker of vision in children with optic pathway gliomas, but normal values for fractional anisotropy (FA), radial diffusivity (RD), and mean diffusivity (MD) in young children have not been defined. In 40 children with neurofibromatosis type I (NF1) and 55 healthy control children between 0-14 years of age, we measured FA, RD and MD in the optic radiations. This study represents the first investigation of normal DTI measures in the optic radiations in young children and demonstrates an altered developmental trajectory in the optic radiations of children with NF1.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.