Previously, we have successfully employed diffusion fMRI (dfMRI) to assess impaired axonal function in experimental autoimmune encephalomyelitis (EAE) mice undergoing visual stimulation. However, the prior dfMRI experiments cannot resolve contributions from retinal dysfunction to the decreased dfMRI changes observed in EAE mice. To address this shortcoming, we implanted an MR-compatible tungsten electrode at lateral geniculate nucleus (LGN) to perform antidromic stimulation of optic nerves. We demonstrated perpendicular apparent diffusion coefficient decreased with antidromic electrical stimulation at LGN bypassing visual input through retina.
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