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Abstract #2284

Heterogeneous increases of cortical mean kurtosis across brain regions during infancy

Huiying Kang1,2,3, Qinmu Peng2,3, Minhui Ouyang2, Xiaolu Tang1, Di Hu1, Hong Zhang1, Yun Peng1, and Hao Huang2,3

1Department of Radiology, Beijing Children’s Hospital, Capital Medical University, Beijing, People's Republic of China, 2Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, United States, 3Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Brain development in the first few years of life is dramatic. The microstructural changes of infant grey matter measured by mean kurtosis, a non-Gaussian diffusion metric more sensitive to cortical microstructure than traditional diffusion metric, is not known. This study recruited 16 typical developing 3-32-months-old infants to investigate microstructural changes of the cerebral cortex by using Diffusion Kurtosis Imaging (DKI). Our results showed positive correlation between the mean kurtosis (MK) value and age. Differentiated age-dependent MK increases among different cortical regions suggest spatiotemporally heterogeneous pattern in cortical development.

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