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Abstract #2290

Structural thalamocortical connectivity in the developing infant brain

Rali Dimitrova1,2, Jonathan O'Muircheartaigh1,2, Judit Ciarrusta1,2, Dafnis Batalle1, Emer Hughes1, Johannes Steinweg1, Emily Perry2, Johanna Kangas2, Ines Pote2, Serena Counsell1, Jo Hajnal1, Declan Murphy2, David Edwards1, and Grainne McAlonan2

1Centre for the Developing Brain, King's College London, London, United Kingdom, 2Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom

Thalamocortical development in early life is crucial for normal brain functioning and abnormalities to these networks are thought to underpin atypical neurodevelopment. However, to date examination of this system in the infant has been hampered by the lack of age-appropriate population atlases. In this study we circumvent this problem by applying independent component analysis to parcellate the thalamocortical projections and their underlying thalamic seed in 6-months-old infants using diffusion MRI.

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