Multimodal diffusion MRI and quantitative MT techniques were used to examine the nature of abnormalities in the corticospinal tracts (CSTs) of amyotrophic lateral sclerosis (ALS) patients. Our data show reductions in axonal volume fraction (AVF) located superiorly to reductions in myelin volume fraction (MVF). We also find extensive decreases in fiber volume fraction (FVF) throughout the entire CST, supporting the hypothesis of axonal loss as the primary pathological mechanism in ALS.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords