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Abstract #2310

Understanding white matter pathology in ALS using a multimodal approach

Matt C Gabel1, Rebecca Broad1, Daniel C Alexander2, Gary H Zhang2, Nigel Leigh3, and Mara Cercignani1

1Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom, 2Centre for Medical Image Computing and Computer Science, University College London, London, United Kingdom, 3Trafford Centre for Medical Research, Brighton and Sussex Medical School, Brighton, United Kingdom

Multimodal diffusion MRI and quantitative MT techniques were used to examine the nature of abnormalities in the corticospinal tracts (CSTs) of amyotrophic lateral sclerosis (ALS) patients. Our data show reductions in axonal volume fraction (AVF) located superiorly to reductions in myelin volume fraction (MVF). We also find extensive decreases in fiber volume fraction (FVF) throughout the entire CST, supporting the hypothesis of axonal loss as the primary pathological mechanism in ALS.

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