Abstract #2312

Graph-based analysis of brain structural MRI data in Multiple System Atrophy

Claudia Testa^1,2, Riccardo Gubellini¹, Stefano Zanigni¹, Lia Talozzi¹, Giulia Giannini³, Giovanna Calandra-Buonaura³, Pietro Cortelli³, Daniel Remondini^2,4, Gastone Castellani^2,4, Paola Fantazzini^4,5, Claudio Bianchini¹, Stefania Evangelisti¹, Caterina Tonon¹, David Neil Manners¹, and Raffaele Lodi¹

¹Department of Biomedical and NeuroMotor Sciences, University of Bologna and Functional MR Unit, Policlinico S. Orsola - Malpighi, Bologna, Italy, Bologna, Italy, ²INFN-Bologna, Bologna, Italy, ³Department of Biomedical and NeuroMotor Sciences, University of Bologna and IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy, ⁴Department of Physics and Astronomy, Bologna, Italy, ⁵Centro Enrico Fermi, Roma, Italy

We investigated the differences in global and regional topological properties and the modular organization of brain networks derived from anatomical covariance of structural MRI between Multiple System Atrophy patients (subdivided in the variants MSA-C, MSA-P) and healthy controls (HC). No differences were found in global, local and small-worldness measures between MSA and HC or between MSA-C and MSA-P. The investigation of modular organization, which reflects differences in properties that underlie the functionality of the brain, has shown a segregation in a cortical-subcortical motor network in patient groups, which may underpin both the typical parkinsonian and cerebellar features of the disorder.

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