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Abstract #2312

Graph-based analysis of brain structural MRI data in Multiple System Atrophy

Claudia Testa1,2, Riccardo Gubellini1, Stefano Zanigni1, Lia Talozzi1, Giulia Giannini3, Giovanna Calandra-Buonaura3, Pietro Cortelli3, Daniel Remondini2,4, Gastone Castellani2,4, Paola Fantazzini4,5, Claudio Bianchini1, Stefania Evangelisti1, Caterina Tonon1, David Neil Manners1, and Raffaele Lodi1

1Department of Biomedical and NeuroMotor Sciences, University of Bologna and Functional MR Unit, Policlinico S. Orsola - Malpighi, Bologna, Italy, Bologna, Italy, 2INFN-Bologna, Bologna, Italy, 3Department of Biomedical and NeuroMotor Sciences, University of Bologna and IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy, 4Department of Physics and Astronomy, Bologna, Italy, 5Centro Enrico Fermi, Roma, Italy

We investigated the differences in global and regional topological properties and the modular organization of brain networks derived from anatomical covariance of structural MRI between Multiple System Atrophy patients (subdivided in the variants MSA-C, MSA-P) and healthy controls (HC). No differences were found in global, local and small-worldness measures between MSA and HC or between MSA-C and MSA-P. The investigation of modular organization, which reflects differences in properties that underlie the functionality of the brain, has shown a segregation in a cortical-subcortical motor network in patient groups, which may underpin both the typical parkinsonian and cerebellar features of the disorder.

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