Abstract #2314

Comprehensive assessment of white matter alterations in Tourette syndrome using automatic whole-brain tract-specific analysis

Chih-Hsien Jerry Tseng^1,2, Wang-Tso Lee^3,4, Shinn-Forng Peng⁵, Chien-Feng Huang¹, Yu-Jen Chen¹, Yun-Chin Hsu¹, and Wen-Yih Isaac Tseng^1,2,4,6

¹Institute of Medical Device and Imaging, National Taiwan University College of Medicine, Taipei, Taiwan, ²Institute of Biomedical Engineering, National Taiwan University College of Medicine, Taipei, Taiwan, ³Department of Pediatrics, National Taiwan University College of Medicine, Taipei, Taiwan, ⁴Graduate Institute of Brain and Mind Sciences, National Taiwan University College of Medicine, Taipei, Taiwan, ⁵Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, ⁶Molecular Imaging Center, National Taiwan University, Taipei, Taiwan

To identify microstructural alteration of white matter tracts in patients with Tourette syndrome (TS), diffusion spectrum imaging data were obtained from 14 patients and 14 matched controls. Whole-brain tract-based automatic analysis was employed to investigate the differences in white matter microstructures between the two groups. As compared with the controls, patients with TS showed altered tract integrity in callosal fibers, cingulum, thalamic radiations and corticospinal tracts. The altered white matter tracts account for clinical hallmarks and pathophysiology of TS, and might serve as structural correlates of TS.

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