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Abstract #2335

Attenuated low frequency oscillations in focal cortical dysplasia

Lalit Gupta1, Paul A Hofman1, René M Besseling2, Jacobus F Jansen1, and Walter H Backes1

1Departments of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, Netherlands, 2Department of Electrical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

The objective was to assess the time-signature of spontaneous BOLD brain fluctuations in patients with focal cortical dysplasia (FCD) and to compare these with other regions and healthy controls. Whole cerebrum resting-state functional MRI time-series were analyzed using three different BOLD measures: wavelet entropy, regional homogeneity and fractional amplitude of low frequency fluctuations. All the three BOLD measures indicated attenuated low frequency oscillations in FCD lesions compared to controls. Also abnormal BOLD activity was found in the proximal and contralateral region, which can complicate the interpretation on what regions are functionally normal, functionally connected or abnormal in patients with FCD.

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