The areas in cerebral white matter appearing hyperintense on T2-weighted and fluid-attenuated inverse recovery (FLAIR) MRI are commonly referred to as white matter lesions (WMLs). Diverse scores and rating systems have been used for evaluating WMLs. However, these visual rating scales are still qualitative and subjective, leading to low reliability and reproducibility. The purpose of this study is to investigate the relation between cognitive functions and WMLs clustered by their profiles of distance from the ventricle, establishing the quantitative and objective evaluation of WMLs.
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