In this study we determine the blood-brain partition coefficient (BBPC) in aging C57Bl6/N mice and the transgenic 129S6/Tg2576 mouse model of Alzheimer’s disease using a calibrated proton density imaging approach. Aging mice demonstrate a 5.5% reduction in BBPC compared to young mice (0.94±0.04 mL/g vs 0.99±0.04 mL/g, p = 0.02), however Tg2576+ mice preliminarily demonstrate an elevated BBPC compared to wild-type controls (01.03±0.04 mL/g vs 1.00±0.05 mL/g). These high quality BBPC maps acquired much faster than previously reported could potentially be used to correct cerebral blood flow measurements derived from arterial spin labeling.
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