Meeting Banner
Abstract #2352

Use of population-specific atlases for brain morphometry: benefits in Alzheimer’s Disease diagnosis decision support for Chinese patients

Bénédicte Maréchal1,2,3, Peipeng Liang4,5,6, Lin Shi7, Tianyi Qian8, Defeng Wang5,6, Tobias Kober1,2,3, Alexis Roche1,2,3, and Kuncheng Li4

1Advanced Clinical Imaging Technology, Siemens Healthcare HC CEMEA SUI DI PI, Lausanne, Switzerland, 2Department of Radiology, CHUV, Lausanne, Switzerland, 3LTS5, EPFL, Lausanne, Switzerland, 4Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China, 5Research Center for Medical Image Computing, Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China, 6Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, China, 7Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, 8MR Collaboration Northeast Asia, Siemens Healthcare, Beijing, China

We investigate the potential of a Chinese-specific brain atlas derived from a large MR database of healthy Chinese subjects to accurately support Alzheimer’s Disease diagnosis using automated brain volumetry in the Chinese population. Our experiments show that disease detection sensitivity is higher than when using either a Westerner-specific atlas and normative ranges or combining a Westerner atlas with Chinese-specific normative ranges. These findings suggest that population-specific models improve the reliability of medical decision support systems based on automated brain volumetry.

This abstract and the presentation materials are available to members only; a login is required.

Join Here