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Abstract #2356

Evaluating glymphatic system by diffusion images: Alzheimer's disease cases analyzed by Diffusion Tensor Image analysis Along Perivascular Space (DTI-ALPS)

Toshiaki Taoka1, Yoshitaka Masutani2, Hisashi Kawai1, Toshiki Nakane1, Kiwamu Matsuoka3, Fumihiko Yasuno3, and Shinji Naganawa1

1Dept. of Radiology, Nagoya University, Nagoya, Japan, 2Dept. of Biomedical Information Sciences, Hiroshima City University, Hiroshima, Japan, 3Dept. of Psychiatry, Nara Medical University, Kashihara, Japan

We tried to evaluate the activity of human glymphatic system by diffusion images. Our subjects were Alzheimer's disease (AD), in which it is known that the activity of the glymphatic system is impaired in animal experiments. We evaluated the diffusivity along the perivascular spaces as well as projection fibers and association fibers, and correlated them with MMSE score. There were significant positive correlation between diffusivity along perivascular spaces and MMSE score, indicating impaired water diffusivity related to AD severity. Our result may indicate that activity of the glymphatic system can be evaluated by diffusion images.

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