Abstract #2356

Evaluating glymphatic system by diffusion images: Alzheimer's disease cases analyzed by Diffusion Tensor Image analysis Along Perivascular Space (DTI-ALPS)

Toshiaki Taoka¹, Yoshitaka Masutani², Hisashi Kawai¹, Toshiki Nakane¹, Kiwamu Matsuoka³, Fumihiko Yasuno³, and Shinji Naganawa¹

¹Dept. of Radiology, Nagoya University, Nagoya, Japan, ²Dept. of Biomedical Information Sciences, Hiroshima City University, Hiroshima, Japan, ³Dept. of Psychiatry, Nara Medical University, Kashihara, Japan

We tried to evaluate the activity of human glymphatic system by diffusion images. Our subjects were Alzheimer's disease (AD), in which it is known that the activity of the glymphatic system is impaired in animal experiments. We evaluated the diffusivity along the perivascular spaces as well as projection fibers and association fibers, and correlated them with MMSE score. There were significant positive correlation between diffusivity along perivascular spaces and MMSE score, indicating impaired water diffusivity related to AD severity. Our result may indicate that activity of the glymphatic system can be evaluated by diffusion images.

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