Abstract #2365

Synergistic Effect of β-Amyloid and Microvascular Abnormality on Longitudinal Cognitive Decline in Elderly Subjects at Risk for Alzheimer’s Disease (AD)

Jun Hua^1,2, M Wyss³, J. M. G. van Bergen⁴, S. J. Schreiner⁴, S. C. Steininger⁴, A. F. Gietl⁴, A. Buck⁵, R. M. Nitsch⁴, K. P. Pruessmann³, H. Lu^1,2, P. C. M. van Zijl^1,2, M. Albert⁶, C. Hock⁴, and P. G. Unschuld⁴

¹Neurosection, Div. of MRI Research, Dept. of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Institute for Biomedical Engineering, University of Zürich and ETH Zürich, Zürich, Switzerland, ⁴Division of Psychiatry Research and Psychogeriatric Medicine, University of Zürich, Zürich, Switzerland, ⁵Division of Nuclear Medicine, University of Zürich, Zürich, Switzerland, ⁶Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Progressive impairment in multiple cognitive domains is a clinical hallmark of Alzheimer’s Disease (AD), which is the most frequent cause for dementia in the elderly and is neuropathologically characterized by both cerebral β-amyloid (Aβ) accumulation and microvascular abnormalities. Here, we report significant co-localization of regions with microvascular abnormalities measured by arteriolar-cerebral-blood-volume (CBVa) MRI and Aβ accumulation measured by PiB-PET in elderly subjects at-risk for AD. Multiple regression analysis suggested that CBVa and Aβ may have a synergistic effect on longitudinal cognitive decline in these subjects . Both variables may need to be considered for secondary prevention trials in such populations.

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