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Abstract #2365

Synergistic Effect of β-Amyloid and Microvascular Abnormality on Longitudinal Cognitive Decline in Elderly Subjects at Risk for Alzheimer’s Disease (AD)

Jun Hua1,2, M Wyss3, J. M. G. van Bergen4, S. J. Schreiner4, S. C. Steininger4, A. F. Gietl4, A. Buck5, R. M. Nitsch4, K. P. Pruessmann3, H. Lu1,2, P. C. M. van Zijl1,2, M. Albert6, C. Hock4, and P. G. Unschuld4

1Neurosection, Div. of MRI Research, Dept. of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 3Institute for Biomedical Engineering, University of Zürich and ETH Zürich, Zürich, Switzerland, 4Division of Psychiatry Research and Psychogeriatric Medicine, University of Zürich, Zürich, Switzerland, 5Division of Nuclear Medicine, University of Zürich, Zürich, Switzerland, 6Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Progressive impairment in multiple cognitive domains is a clinical hallmark of Alzheimer’s Disease (AD), which is the most frequent cause for dementia in the elderly and is neuropathologically characterized by both cerebral β-amyloid (Aβ) accumulation and microvascular abnormalities. Here, we report significant co-localization of regions with microvascular abnormalities measured by arteriolar-cerebral-blood-volume (CBVa) MRI and Aβ accumulation measured by PiB-PET in elderly subjects at-risk for AD. Multiple regression analysis suggested that CBVa and Aβ may have a synergistic effect on longitudinal cognitive decline in these subjects . Both variables may need to be considered for secondary prevention trials in such populations.

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