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Abstract #2377

What Happens to the Hippocampus 12-months After Training? A Longitudinal Linear Mixed Effects Model Analysis of Mild Cognitive Impairment in the SMART Trial

Kathryn Mary Broadhouse1, Chao Suo1,2,3,4, Maria Fiatarone Singh5,6, Nicola Gates1,3,4, Wei Wen4,7, Perminder Sachdev4,7, Henry Brodaty4,8, Nidhi Saigal9, Nalin Singh9, Guy Wilson9, Jacinda Meiklejohn9, Bernhard Baune10, Michael Baker5,11, Nasmin Foroughi12, Yi Wang9,13, Yorgi Marvos11, and Michael J Valenzuela1,14

1Regenerative Neuroscience Group, Brain and Mind Centre, Sydney, Australia, 2Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neuroscience, Monash University, Sydney, Australia, 3School of Psychiatry, University of New South Wales, Sydney, 4Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, 5Exercise Health and Performance Faculty Research Group, Faculty of Health Sciences and Sydney Medical School, The University of Sydney, 6Hebrew SeniorLife and Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, 7Neuropsychiatric Institute, Prince of Wales Hospital, Sydney, NSW, Australia, 8Dementia Collaborative Research Centre, University of New South Wales, Sydney, NSW, Australia, 9Exercise Health and Performance Faculty Research Group, Faculty of Health Sciences, The University of Sydney, Lidcombe, NSW, Australia., 10Department of Psychiatry, School of Medicine, University of Adelaide, Adelaide, SA, Australia, 11School of Exercise Science, Australian Catholic University, Strathfield, NSW, Australia., 12Clinical and Rehabilitation Research Group, Faculty of Health Sciences, The University of Sydney, Lidcombe, NSW, Australia., 13Department of Medicine and the Diabetes Center, University of California, San Francisco, San Francisco, CA, USA, 14School of Medical Sciences, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.

Mild cognitive impairment (MCI) increases future risk of dementia, however, several studies have shown that mental and physical exercise reduce this risk. From the Study of Mental Activity and Resistance Training (SMART) we have previously shown significantly improved global cognitive function immediately after 6 months of progressive resistance training in MCI. In this analysis, we compare longitudinal hippocampal volume change in MCI using linear mixed effects models over an 18-month period comprised of a 6-month training phase and a 12-month post training follow-up. Our results show both isolated cognitive and progressive resistance training significantly diminished the rate of left hippocampal atrophy compared to a double sham intervention across training and an extended follow-up period.

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