Abstract #2383

Thalamic Atrophy following mTBI is Associated with Persistent Post-Concussive Symptoms and Cognitive Fatigue

Jiachen Zhuo¹, Li Jiang¹, Chandler Sours¹, Prashant Raghavan¹, Jerry L Prince², and Rao P Gullapalli¹

¹Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ²Electrical and Computer Engineering, Johns Hopkins University

Even mild TBI patients with negative CT and MRI may experience persistent post-concussive symptoms (PCS) and declined cognition more than 3 months post injury. In this prospective study of regional brain volume changes in mTBI patients, we found progressive thalamic atrophy from acute to chronic stages post injury, especially within the patient group that showed persistent PCS at 6 months. Thalamic volume atrophy also correlated with cognitive fatigue and processing speed within the same symptomatic mTBI group. Further studies on vulnerability of the thalamus may provide more insights into TBI recovery and lead to potential Therapies.

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