Abstract #2407

Quantitative Measurement of Cerebral Blood Volume Across 173 Brain Regions In Anethesia and Response to CO2

Liam Timms¹, Codi Gharagouzloo², Ju Qiao³, Zihang Fang¹, Praveen Kulkarni⁴, Anne van De Ven¹, and Craig Ferris⁵

¹Physics, Northeastern University, Boston, MA, United States, ²Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Bioengineering, Northeastern University, Boston, MA, United States, ⁴Psychology, Northeastern University, Boston, MA, United States, ⁵Physics, Bioengineering, Northeastern University, Boston, MA, United States

We use a technique based on positive contrast quantitative imaging of super paramagnetic iron oxide nanoparticles with optimized parameters which we have previously introduced called QUTE-CE to measure CBV across a detailed rat brain atlas. This is done for an anesthetized state and then changes in an awake hypercapnic state are additionally quantified. The former provides a baseline for future work and reflects evolutionary and developmental forces. The latter demonstrates the potential of the technique for measuring changes in CBV and provides a measure of perfusion reserve.

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