Abstract #2435

COMPARISON OF BRAIN ATROPHY MEASURES FOR CLINICAL USE IN MULTIPLE SCLEROSIS

Loredana Storelli¹, Elisabetta Pagani¹, Maria Assunta Rocca¹, Wim Van Hecke², Nicola De Stefano³, Alex Rovira⁴, Jaume Sastre-Garriga⁵, Jacqueline Palace⁶, and Massimo Filippi¹

¹Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, ²R&D icometrix Leuven Belgium, Leuven, Belgium, ³Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy, ⁴Department of Radiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain, ⁵Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Department of Neurology/Neuroimmunology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain, ⁶Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

Aim of this study was to test two available methods (FSL-SIENAx/SIENA and Icometrix-MSmetrix) used for brain atrophy estimation on MR images of multiple sclerosis (MS) patients for a future clinical use. The accuracy and precision of these methods, as well as their main steps, were evaluated on 3D-T1 and 3DT2-FLAIR sequences of a simulated dataset, MRI of MS patients acquired at different scanners, field strengths, and on longitudinal dataset. From the comparison, SIENAx/SIENA showed a worst image registration, brain extraction and higher dependence on image acquisition quality than MSmetrix software. FSL pipelines showed better accuracy for cross-sectional and longitudinal analysis.

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