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Abstract #2435

COMPARISON OF BRAIN ATROPHY MEASURES FOR CLINICAL USE IN MULTIPLE SCLEROSIS

Loredana Storelli1, Elisabetta Pagani1, Maria Assunta Rocca1, Wim Van Hecke2, Nicola De Stefano3, Alex Rovira4, Jaume Sastre-Garriga5, Jacqueline Palace6, and Massimo Filippi1

1Neuroimaging Research Unit, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 2R&D icometrix Leuven Belgium, Leuven, Belgium, 3Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy, 4Department of Radiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain, 5Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Department of Neurology/Neuroimmunology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain, 6Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

Aim of this study was to test two available methods (FSL-SIENAx/SIENA and Icometrix-MSmetrix) used for brain atrophy estimation on MR images of multiple sclerosis (MS) patients for a future clinical use. The accuracy and precision of these methods, as well as their main steps, were evaluated on 3D-T1 and 3DT2-FLAIR sequences of a simulated dataset, MRI of MS patients acquired at different scanners, field strengths, and on longitudinal dataset. From the comparison, SIENAx/SIENA showed a worst image registration, brain extraction and higher dependence on image acquisition quality than MSmetrix software. FSL pipelines showed better accuracy for cross-sectional and longitudinal analysis.

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