Abstract #2445

Cerebral Blood Flow of CASL Perfusion Imaging to Predict Neurobehavioral Outcome in a Murine Model of Subarachnoid Hemorrhage

Kazumasu Sasaki^1,2, Tatsushi Mutoh^2,3, Kazuhiro Nakamura^2,3, Tomoko Mutoh^3,4, Yasuko Tatewaki³, Tomoyuki Yambe¹, Yasuyuki Taki³, and Tatsuya Ishikawa²

¹Department of Preclinical Evaluation, Institute of Development, Aging and Cancer (IDAC), Tohoku University, Sendai, Japan, ²Research Institute for Brain and Blood Vessels-AKITA, Akita, Japan, ³Department of Nuclear Medicine and Radiology, IDAC, Tohoku University, Sendai, Japan, ⁴Graduate School of Psychology, Kobe Shoin Women’s University, Kobe, Japan

Early brain injury/ischemia is a recent therapeutic target of subarachnoid hemorrhage (SAH) that contributes to triggering delayed cerebral ischemia (DCI) [1]. However, little is known about the role of cerebral blood flow (CBF) and neurobehavioral profiles at acute stage on functional outcome of the rodent model to simulate clinical severity early after SAH. The present study demonstrated the feasibility of MRI-based CBF measurements using the continuous arterial spin labeling (CASL) perfusion images for precise grading of the severity in a murine model of endovascular perforation model of SAH.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.