In view of the failure of neurocentric treatments for ischemic stroke, this work examines a pleiotropic modulation of the neurogliovascular unit exerts beneficial effects in the treatment of brain stroke. Oxydative metabolism of glucose in the peri-ischemic tissue has potentially detrimental effects on tissue; in contrast, ketones’ metabolism - in light of the reduced amount of oxygen required - provides a safer alternative. We employed functional CASL, in situ electrophysiology, and biochemical analysis to show short-term benefits of early administration of β-Hydroxybutyrate to metabolically challenged brain tissue following focal ischemia.
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