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Abstract #2447

Modulation of the peri-infarct neurovascular function by Beta-Hydroxybutyrate

Paolo Bazzigaluppi1, Evelyn Lake2, Margaret Koletar3, Rafal Janik4, James Mester5, Conner Adams6, Peter Carlen7, and Bojana Stefanovic4

1Medical biophysics, Sunnybrook Research institute, Toronto, ON, Canada, 2Yale University, CT, United States, 3Sunnybrook Research Institute, 4Sunnybrook Research Institute, ON, Canada, 5Sunnybrook Research Center, ON, Canada, 6ON, Canada, 7Krembil Research Intitute, Toronto, ON, Canada

In view of the failure of neurocentric treatments for ischemic stroke, this work examines a pleiotropic modulation of the neurogliovascular unit exerts beneficial effects in the treatment of brain stroke. Oxydative metabolism of glucose in the peri-ischemic tissue has potentially detrimental effects on tissue; in contrast, ketones’ metabolism - in light of the reduced amount of oxygen required - provides a safer alternative. We employed functional CASL, in situ electrophysiology, and biochemical analysis to show short-term benefits of early administration of β-Hydroxybutyrate to metabolically challenged brain tissue following focal ischemia.

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