The stroke is a common cause of death. The technique of high-resolution magnetic resonance imaging (HR-MRI) has been used to depict the vessel wall. Our study aimed to evaluate thetherapeutic efficiency of the symptomatic atherosclerotic plaque in middle cerebral artery by 3D High-resolution MRI. And we compared the imaging and clinical symptom before and after the therapy. The diagnosis of the imaging is consistent with the clinical symptom. 3D High-resolution MRI is a potential imaging technology to evaluate therapeutic efficiency of atherosclerotic plaque in middle cerebral artery.