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Abstract #2455

Association of Atherosclerotic Plaque Characteristics between Intracranial and Extracranial Carotid Arteries in Symptomatic Patients: A 3D Multicontrast MR Vessel Wall Imaging Study

Yilan Xu1, Chun Yuan2,3, Zechen Zhou4, Le He2, Rui Li2, Yuanyuan Cui5, Zhuozhao Zheng1, and Xihai Zhao2

1Department of Radiology, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, People's Republic of China, 2Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, People's Republic of China, 3Department of Radiology, University of Washington, Seattle, United States, 4Philips Research China, Philips Healthcare, Beijing, People's Republic of China, 5Department of Radiology, PLA General Hospital, Beijing, People's Republic of China

This study investigated the correlation between intracranial and extracranial carotid artery atherosclerotic disease in symptomatic patients. We found that extracranial artery disease showed larger plaque burden than intracranial artery disease. In addition, the number of extracranial plaques was found to be associated with intracranial plaque number and maximum wall thickness (MaxWT) and the extracranial carotid MaxWT was independently associated with intracraninal artery stenosis. The association of extracranial artery plaque number and MaxWT with severity of intracranial artery disease suggests that the plaque burden measurements in extracranial carotid arteries might be effective indicators for the severity of intracranial atherosclerosis.

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