Abstract #2457

Relationship between cerebral blood flow and water diffusion in the brain of misery perfusion model mice

Takuya Urushihata¹, Hiroyuki Takuwa¹, Chie Seki¹, Yasuhiko Tachibana¹, Jeff Kershaw¹, Yuhei Takado¹, Nohuhiro Nitta¹, Ichio Aoki¹, Hiroshi Ito², and Takayuki Obata¹

¹National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan, ²Fukushima Medical University, Fukushima, Japan

We have investigated degeneration of the nerve fibers in chronic cerebral hypoperfusion model mice using DTI. Simple t-tests indicated that there are significant differences in CBF between the control and occluded sides of the brain, but there was no significant difference for MD. However, analysis of covariance showed that MD was strongly correlated with CBF, and that there were significant differences in MD between the contra- and ipsilateral sides. The result suggests degeneration of the nerve fibers due to chronic hypoperfusion. It is also suggested that CBF-related signal changes might be important for pathological diagnosis with DTI.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.