Abstract #2469

Diffusion discriminant for mild cognitive impairment in Parkinson’s disease

Aziz M. Ulug^1,2, Esin Ozturk-Isik¹, Ani Kicik^3,4, Emel Erdogdu⁵, Sevim Cengiz¹, Dilek Betul Arslan¹, Seda Buker⁶, Ali Bayram^3,4, Cigdem Ulasoglu-Yildiz^3,4, Elif Kurt^3,4, Zeynep Tufekcioglu⁶, Basar Bilgic⁶, Hasmet A. Hanagasi⁶, Tamer Demiralp^3,7, and Hakan Gurvit⁶

¹Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, ²CorTechs Labs, San Diego, CA, United States, ³Hulusi Behcet Life Sciences Research Center, Istanbul University, Istanbul, Turkey, ⁴Department of Neuroscience, Istanbul University, Istanbul, Turkey, ⁵Institute of Psychology and Cognition Research, University of Bremen, Bremen, Germany, ⁶Department of Neurology, Istanbul University, Istanbul, Turkey, ⁷Department of Physiology, Istanbul University, Istanbul, Turkey

High percentage of Parkinson’s disease patients develop cognitive impairment during the course of the disease progression. An imaging marker that can identify the patients who will develop cognitive impairment would be helpful in deciding the treatment strategy for these patients. We have used diffusion tensor imaging to identify brain structures which can be utilized to discriminate between Parkinson’s patients with mild cognitive impairment and without cognitive deficits.

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