Abstract #2471

Analysis of the Substantia Nigra from Parkinson’s disease patients and control subjects using co-registered DTI and QSM data

Gerd Melkus^1,2, Santanu Chakraborty^1,2, Fahad A Essbaiheen^1,2,3, David A Grimes ^4,5, and Tiago Mestre^4,5

¹Medical Imaging, The Ottawa Hospital, Ottawa, ON, Canada, ²Radiology, University of Ottawa, Ottawa, ON, Canada, ³King Saud University, Riyadh, Saudi Arabia, ⁴Parkinson’s Disease and Movement Disorders Center, The Ottawa Hospital Research Institute, Ottawa, ON, Canada, ⁵Department of Medicine, University of Ottawa, Ottawa, ON, Canada

Different quantitative MRI techniques like Diffusion Tensor Imaging (DTI) and Quantitative Susceptibility Imaging (QSM) have been used to evaluate the substantia nigra (SN) in patients with Parkinson’s disease (PD). When multimodal MRI studies are applied to acquire several quantitative parameters the analysis of each of these datasets on an individual ROI basis can time consuming. In this study we are using a co-registration approach to a standard brain template for evaluating quantitative MR data (from DTI and QSM) in the SN of PD patients and controls.

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