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Abstract #2474

Cerebral Perfusion Correlates of MAPT and COMT Genotypes for  Mild Cognitive Impairment in Parkinson’s Disease at 3T

Dilek Betul Arslan1, Ani Kıçik2,3, Sevim Cengiz1, Emel Erdogdu4, Seda Buker 5, Zeynep Tufekcioglu 5, Aziz Mufit Ulug1,6, Basar Bilgic5, Hakan Gurvit5, Tamer Demiralp2,7, Erdem Tuzun8, Hasmet Hanagasi5, and Esin Ozturk-Isik 1

1Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, 2Hulusi Behçet Life Sciences Research Laboratory, Istanbul University, Istanbul, Turkey, 3Istanbul University, Institute of Experimental Medicine, Department of Neuroscience, Istanbul, Turkey, 4Institute of Psychology and Cognition Research, University of Bremen, Bremen, Germany, 5Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, 6CorTechs Labs, San Diego, CA, USA, 7Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, 8Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey

The purpose of this study is to investigate the cerebral perfusion correlates of microtubule-associated protein tau (MAPT) and catechol-O-methyl transferase (COMT) genotypes in Parkinson’s Disease with mild cognitive impairment (PD-MCI) and PD with normal cognition (PD-CN) using multi inversion time pulsed arterial spin labelling magnetic resonance imaging (pASL-MRI). Cerebral blood flow (CBF) and arterial blood volume (aBV) maps of patients were calculated by using general kinetic model and compared between different genotypes of PD-MCI and PD-CN. It was found that PD-MCI with H1/H1 genotype of MAPT gene had a lower cerebral perfusion than PD-CN with H1/H2 genotype.

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