Abstract #2474

Cerebral Perfusion Correlates of MAPT and COMT Genotypes for Mild Cognitive Impairment in Parkinson’s Disease at 3T

Dilek Betul Arslan¹, Ani Kıçik^2,3, Sevim Cengiz¹, Emel Erdogdu⁴, Seda Buker ⁵, Zeynep Tufekcioglu ⁵, Aziz Mufit Ulug^1,6, Basar Bilgic⁵, Hakan Gurvit⁵, Tamer Demiralp^2,7, Erdem Tuzun⁸, Hasmet Hanagasi⁵, and Esin Ozturk-Isik ¹

¹Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, ²Hulusi Behçet Life Sciences Research Laboratory, Istanbul University, Istanbul, Turkey, ³Istanbul University, Institute of Experimental Medicine, Department of Neuroscience, Istanbul, Turkey, ⁴Institute of Psychology and Cognition Research, University of Bremen, Bremen, Germany, ⁵Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, ⁶CorTechs Labs, San Diego, CA, USA, ⁷Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey, ⁸Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey

The purpose of this study is to investigate the cerebral perfusion correlates of microtubule-associated protein tau (MAPT) and catechol-O-methyl transferase (COMT) genotypes in Parkinson’s Disease with mild cognitive impairment (PD-MCI) and PD with normal cognition (PD-CN) using multi inversion time pulsed arterial spin labelling magnetic resonance imaging (pASL-MRI). Cerebral blood flow (CBF) and arterial blood volume (aBV) maps of patients were calculated by using general kinetic model and compared between different genotypes of PD-MCI and PD-CN. It was found that PD-MCI with H1/H1 genotype of MAPT gene had a lower cerebral perfusion than PD-CN with H1/H2 genotype.

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