Abstract #2481

Evaluation of Neuromelanin-MRI parameters and Volumetric changes with Parkinson’s Disease Progression

Miguel A Carvalho^1,2, Sofia Reimão³, Margherita Fabbri⁴, Daisy Abreu⁴, Jorge Campos³, Joaquim F Ferreira^4,5, and Rita G Nunes^1,6

¹Instituto de Biofísica e Engenharia Biomédica, Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal, ²Physics Department, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Lisbon, Portugal, ³Neurological Imaging Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Lisbon, Portugal, ⁴Clinical Pharmacology Unit, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal, ⁵Neurology Department, Hospital de Santa Maria - Centro Hospitalar Lisboa Norte, Lisbon, Portugal, ⁶Institute for Systems and Robotics / Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal

This study aimed to characterize changes in Neuromelanin-sensitive MR images with Parkinson’s Disease (PD) progression. The area of high signal intensity in the substantia nigra (SN) and its contrast ratio (CR) were assessed in early and late stage PD (LSPD) patients, and in healthy individuals. The relative hippocampus and midbrain volumes were also estimated from anatomical MPRAGE scans. The SN area was found to be markedly reduced in LSPD compared to early stages of the disease and so could be a useful tool to evaluate disease progression. The decrease in relative hippocampus volume could indicate cognitive impairment, characteristic of LSPD.

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