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Abstract #2486

A Behavioural and MRI Structural Study of Early Stage 6-OHDA Parkinson’s Disease Rat Model

Brigida Ranieri1,2, Ilaria Rosa1, Davide Di Censo1, Angelo Galante1,2,3, Eugenio Scarnati4, Tiziana Marilena Florio1,2, and Marcello Alecci1,2,3

1Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy, 2Laboratori Nazionali del Gran Sasso, Istituto Nazionale di Fisica Nucleare, L'Aquila, Italy, 3SPIN-CNR Institute, CNR, L'Aquila, 4Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy

We established the correlation between behaviour and functional structures in an early stage of 6-OHDA PD rat model. Behavioural data reveal that receptor sensitization develops few days after dopaminergic injury. The apomorphine-induced amplification of the motor asymmetry over time is paired to striatal shrinkage and alteration of the GM/WM area in the ipsilateral striatum, as revealed by immunohistology and ex-vivo high-resolution MRI analysis.

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