Abstract #2486

A Behavioural and MRI Structural Study of Early Stage 6-OHDA Parkinson’s Disease Rat Model

Brigida Ranieri^1,2, Ilaria Rosa¹, Davide Di Censo¹, Angelo Galante^1,2,3, Eugenio Scarnati⁴, Tiziana Marilena Florio^1,2, and Marcello Alecci^1,2,3

¹Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy, ²Laboratori Nazionali del Gran Sasso, Istituto Nazionale di Fisica Nucleare, L'Aquila, Italy, ³SPIN-CNR Institute, CNR, L'Aquila, ⁴Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy

We established the correlation between behaviour and functional structures in an early stage of 6-OHDA PD rat model. Behavioural data reveal that receptor sensitization develops few days after dopaminergic injury. The apomorphine-induced amplification of the motor asymmetry over time is paired to striatal shrinkage and alteration of the GM/WM area in the ipsilateral striatum, as revealed by immunohistology and ex-vivo high-resolution MRI analysis.

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