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Abstract #2489

Which one is a better marker for the diagnosis of Parkinson’s disease: T1 MRI or DTI

Ehsan Adeli1, Guorong Wu1, Min-Jeong Kim1, and Dinggang Shen1

1Department of Radiology and Biomedical Research Imaging Center (BRIC), University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Parkinson's disease (PD) is a common neurodegenerative disorder, which progresses slowly and affects the quality of life dramatically. In this paper, we use the T1 MRI and DTI data from the PPMI study to analyze the effect of each modality through investigating the brain regions, and determine which modality can be a better marker at diagnosing the disease. For this purpose, we propose a joint feature selection and max-margin classification framework, in which we select features that best benefit the classification scheme. Our results show that the brain structural connectivity studies using DTI leads to better results.

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