Abstract #2531

The cytoarchitectonic anterior-posterior subdivision of BA4 reveals different resting state networks suggestive of maladaptive mechanisms in MS

Adnan A.S. Alahmadi^1,2, Rebecca S. Samson¹, Matteo Pardini^1,3, Egidio D'Angelo^4,5, Karl J. Friston⁶, Ahmed T. Toosy¹, and Claudia AM Gandini Wheeler-Kingshott^1,4,7

¹UCL Institute of Neurology, Queen Square MS Centre, University College London, London, United Kingdom, ²Department of Diagnostic Radiology, Faculty of Applied Medical Science, KAU, Jeddah, Saudi Arabia, ³Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics and Maternal and Child Health, University of Genoa, Genoa, Italy, ⁴Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ⁵Brain Connectivity Centre, C. Mondino National Neurological Institute, Pavia, Italy, ⁶Wellcome Centre for Imaging Neuroscience, University College London, London, United Kingdom, ⁷Brain MRI 3T Mondino Research Center, C. Mondino National Neurological Institute, Pavia, Italy

This study investigates whether it is possible to characterise different resting state fMRI (rsfMRI) networks connected to the cytoarchitectonic subdivisions of Brodmann area 4 (BA4) and how these networks behave in the presence of multiple sclerosis (MS). We showed that each sub-region identifies different rsfMRI networks, with the BA4p network including more associative and higher order functional areas whereas the BA4a network includes more force-related and motor areas. In MS, functional connectivity to the right hemisphere was lost and was positively correlated with the 9-HPT, suggesting a maladaptive mechanism rather than a compensatory mechanism.

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